| Objective:With the help of the ancient and modern medical case cloud platform,data mining was carried out on the traditional Chinese medicine prescriptions for the treatment of diabetes foot in the recent 15 years,so as to analyze the medication law of traditional Chinese medicine for the treatment of diabetes foot,discuss and summarize its treatment ideas and characteristics,and hope to have some reference significance for the clinical treatment of diabetes foot.Methods:Retrieving the literature on Chinese medicine treatment of diabetic foot from China How Net,CBM,Wanfang Data and VIP platform from January 2006 to December 2021,176 eligible documents were selected.A total of 210 prescriptions were selected,including 81 oral medicine prescriptions and 129 external treatment prescriptions.After sorting out data,the Chinese herbal medicine oral database and Chinese medicine external treatment database were established respectively.Record the ancient and modern medical case cloud platform respectively,standardize the data,then analyze the frequency and compatibility rule of Chinese medicine for treating diabetic foot by using the data statistics and analysis function of software.Results:1.The statistical results of frequency of traditional Chinese medicine（TCM）showed that: a total of 136 TCMs were listed in internal medicine formulas,with a total frequency of 884 times,and the top 10 ranked TCMs for frequency in turn were Radix Astragali,Radix Angelicae sinensis,radix paeoniae rubra,Radix Glycyrrhizae,Rhizoma Chuanxiong,radix salviae miltiorrhizae,radix rehmanniae,Rhizoma dilongi,and Radix galliforme;A total of 177 Chinese medicines were listed in the external prescription formula with a total frequency of 1228 times,and the top 10 ranked Chinese medicines with a total frequency in turn were Honghua,frankincense,Danggui,Guizhi,myrrhiza,Chishao,huanghuang,Chishao,Huangbai,and tungski herb（where Honghua and frankincense were listed in the1 st place）.2.The statistical results of four and five attributes of drugs showed that the four attributes of TCM for internal medicine were most used at the temperature,followed by the flat,slightly cold,and cold attributes;Five attributes were used most with sweet,followed by bitter,and pungent.The tetraqi attribute of exo Chinese medicine is also used most for warmth,followed by cold,and flat;Five attributes were used most for pungency,followed by bitter,sweet.3.Medicinal meridian attributes the statistical results showed that the order of the meridian attributes of internal medicine in the top 6 ranking of frequency of use was liver meridian,spleen meridian,heart meridian,lung meridian,stomach meridian,and kidney meridian;The ascribed properties of TCM for external treatment are liver meridian,heart meridian,spleen meridian,lung meridian,kidney meridian,and stomach meridian in the order of frequency ranking the first 6 points.4.Drug efficacy attributes the statistical results showed that the efficacy ranking in the top 5 order of frequency of internal medicine use was as follows: clearing heat and detoxification,clearing heat and herbal blood,regulating menorrhea and analgesia,moistening the intestine and eliminating blood stasis and relieving pain;The efficacy of external medicines used frequently in the top5 ranking is in the order of eliminating swelling and raw muscle,regulating meridian pain,dissipating stasis and relieving pain,clearing heat and detoxification,relaxing and activating qi,and removing wind and eliminating dampness（where it is in the 5th position for removing body heat,removing wind and removing dampness）.5.It is obtained by the drug association rule: there are eight pairs of combinations in internal medicine,which are in the order of Angelica sinensis radix,Achyranthes Bidentatae radix,Achyranthes Bidentatae radix,Radix Paeoniae Radix Astragali Radix,Radix Glycyrrhizae Radix Angelicae Sinensis radix,Rhizoma Chuanxiong Radix Astragali Radix,and Radix Salviae Radix Astragali Radix;External traditional Chinese medicines（TCM）have nine pairs of combinations in the following order: frankincense myrrhiza,safflower Angelica sinensis,frankincense jixuevine,Guizhi jixuevine,Honghua frankincense,Honghua jixuevine,frankincense Guizhi,Guizhi Honghua,and myrrhizal Honghua.6.Obtained by drug cluster analysis: the internal medicine herbs were divided into six groups,namely,group 1 Radix Astragali and Radix Angelicae sinensis,group 2 radix paeoniae rubra,Radix Achyranthes Bidentatae,Radix dilongi,group 3 Radix Scutellariae,Rhizoma Chuanxiong,Carthamus tinctorius,and peach kernel,group4 Radix Glycyrrhizae,Radix scrophularis,Radix Lonicera,Cortex Phellodendri,group 5 radix salviae miltiorrhizae,group 6 Radix cinnamomi,radix puerariae,radix rehmanniae radix rehmanniae,Radix Rehmanniae hirsutae,Radix frankincense,Radix Paeoniae Alba;The traditional Chinese medicines（TCM）for external treatment were divided into nine groups,which were Honghua and Danggui in group1,frankincense,myrrhiza,Cinnamomum clade,jixuevine in group 2,Astragalus membranaceus and borneol in group 3,bitter ginseng,rhubarb and Huangbo in group 4,Chishao,chuanxiong and Tao Ren in group 5,Achyranthes Bidentatae root,Glycyrrhizae Radix et Rhizoma,Atractylodes Rhizoma in group 6,Wilms Rhizoma,hematoxylin and Salvia Miltiorrhizae in group 5,Dioscoreae radix,extensor tendon herb in group 7,Baizhi Radix Angelicae Sinensis Radix purpureus in group 7,Xuezhi Radix et Rhizoma with Coptidis Rhizoma and poria cocos,group 9 papaya,Zanthoxylum avicennae,caprifolia sinensis,evodiam Fructus,asarum sinensis,Dilong and Aiye.7.Obtained through the analysis of pharmaceutical societies:internal medicine was divided into 5 societies,and external medicine was divided into 4 societies.8.Obtained by drug complex network analysis: the core drugs used in traditional Chinese medicine（TCM）are Radix Astragali,Radix Angelicae sinensis,Radix achyrrhizae,radix paeoniae rubra,Rhizoma Chuanxiong,Radix Dillon,and Carthamus tinctorius;The core drugs used in traditional Chinese medicine（TCM）for external treatment are frankincense,myrrhiza,Angelica sinensis,safflower,Cinnamomum Ramulus,chikusetsu,Dioscoreae radix,and Astragalus membranaceus.Conclusion:The treatment of diabetic foot with traditional Chinese medicine,regardless of oral and external treatment,combines deficiency and excess syndrome differentiation,etiology syndrome differentiation,viscera syndrome differentiation,Qi and blood body fluid syndrome differentiation,and the treatment is always carried out by supplementing qi and blood,promoting blood circulation and removing blood stasis,clearing heat and detoxification,which provides ideas for guiding the clinical diagnosis and treatment of diabetic foot. |
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