| Objective: To investigate the clinical significance of fascin expression in gastric carcinoma.Methods: Detect the expression of fascin in 76 tissues of gastric carcinoma, their own normal gastric tissues in contrast, and also the lymph nodes involved by gastric carcinoma in 53 cases thereinto with immunohistochemical stain. We also detected the expression of nm23 and C-erbB-2 in the tissues of gastric carcinoma.Result: There is no expression of fascin in normal gastric tissues. Fascin proteins are positive in 24 cases of the 76 gastric carcinoma, and they correlate with pathological style (WHO classification and Lauren's typing),TNM staging,serosal invasion,lymphatic metastasis,distant metastasis,the expression of nm23 and C-erbB-2, and so on. They don't correlate with age,gender,histodifferentiation,cancer embolus in vessel and so on. The expressions of fascin in primary masses and their metastatic lymph nodes are consistent, in the cases with metastasis.Conclusion: The expression of fascin is positive in the... |
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