Expression Of PTTG And FGF-2 In Prostate Cancer

Prostate cancer (PCa) is one of the common urological malignant neoplasms and it is the second leading cause of death of cancer in American males. In recent years, with the ageing of the population and improved living conditions, the incidence of PCa shows an increasing trend in China. Prostate cancer has affected the health of Chinese males seriously. PCa is caused by many risk factors. Age, race, inheritance, diet, environmental factors, and steroid hormones were considered to be the risk factors of prostate cancer. Change in androgen level has important linkage to these factors. Combined with androgen receptors which are located on prostate epithelium, androgen regulates the expression of androgen responsive gene and causes a series of changes in prostate cells.Prostate cancer is insensitive to radiotherapy and chemotherapy, and endocrinetherapy has become a conventional treatment for prostate cancer, but in a considerable number of patients the tumor eventually progresses to an androgen...