Expressions Of PTTG, OPN And BFGF Protein In Cervical Squamous Cell Carcinoma And Their Clinical Significance

Objective:The expressions of PTTG, OPN and bFGF protein in invasive squamous cell carcinoma of cervix and their clinical significance were investigated.Methods:The expressions of PTTG, OPN, bFGF, CD34 and Ki-67 protein in 28 cases of normal cervical epithelium (NCE), 36 cases of cervical intraepithelial neoplasm (CIN) and 68 cases of squamous cell carcinoma of cervix (SCC) were detected by immunohistochemistry SP method. The association of the expressions of PTTG, OPN and bFGF in SCC group with microvessel density (MVD), cancer cell proliferation index (PI), invasion, metastasis, and prognosis was analysed.Results:The positive expression of PTTG increased remarkably from NCE to CIN, and then to SCC accordingly (P<0.01). The expression of PTTG in SCC correlated with FIGO staging, pelvic lymph node metastasis, stroma and intravascular infiltration (P<0.05). In the cases with FIGO stagingâ…¡, pelvic lymph node metastasis, deeper stroma and intravascular infiltration, the expression of PTTG was significantly higher than that in those without the conditions mentioned above (P<0.05). The PI in higher expression of PTTG in CIN group was higher than the lower expressed, but the statistical significance had no difference (P=0.053). The expression of PTTG in SCC group was not correlated with PI, MVD and survival rate, respectively (P>0.05).The expression of OPN had no difference from NCE to CIN (P>0.05), and increased remarkably from CIN to SCC (P<0.01). The expression of OPN in SCC was correlated with FIGO staging and intravascular infiltration (P<0.05). In the cases with FIGO stagingâ…¡and intravascular infiltration, the expression of OPN was significantly higher than that in those without the conditions mentioned above (P<0.05). The expressions of OPN in SCC group was significantly positive correlated with PI (r=0.422,P=0.000), but not related to MVD, survival rate and PTTG expression (P>0.05).The expression of bFGF increased remarkably from NCE and CIN, and then to SCC (P<0.01). The expression of bFGF in SCC was related to pelvic lymph node metastasis and intravascular infiltration (P<0.05). In the cases with pelvic lymph node metastasis and intravascular infiltration, the expression of bFGF was significantly higher than that in those without the conditions mentioned above (P<0.05). The expression of bFGF in SCC group was significantly positive correlated with MVD (r=0.326, P=0.007), but not related to PI and survival rate (P>0.05). The expression of bFGF in SCC group was significantly positive correlated with OPN (r=0.259,P=0.016), but not related to PTTG (P>0.05).Conclusions:The over-expression of PTTG, OPN and bFGF may participate in pathogenesis and metastasis in cervical squamous cell carcinoma. The over expression of PTTG and OPN may result in rapid proliferation of cervical intraepithelial neoplasm and cancer cell. The over expression of bFGF may lead to great increase of tumor angiogenesis. The over-expression of PTTG, OPN and bFGF in SCC group may lead to cancer invasion and metastasis. Detection expressions of PTTG, OPN and bFGF in SCC may be of value in further understanding of the biological behavior and predicting the prognosis of squamous carcinoma of cervix.