| During the process of high intensity exercise, in the human body, free radicals generatedwill increase. Because the body’s own antioxidant system is difficult to remove excess freeradicals, it was the occurrence of sports injuries and sports fatigue. The supplement of theexogenous antioxidant can delay the occurrence and continuation of various chronicpathological process and exercise fatigue caused by oxidative stress, and it also can improveexercise, especially aerobic exercise capacity. The former Soviet Union scientists found thatRhodiola can extend the muscle load time and promote protein hydrolysis. Biochemicalmeasurements showed that after the muscle load movement the lactic acid can enhanced thesynthesized of the Rhodosin (200mg/kg) in the still rat muscle, decreased the concentration ofintrahepatic glycogen, and increased the activation of anaerobic glycolysis. It also canincreased the load of lipid metabolism in rats, reduced consumption of glycogen in themuscles and brain, to promote the normalization of load muscle nitrogen metabolism index.Purpose of the experiment: In the Sports training, the generation, accumulation andelimination of sports fatigue the is a continuous process. Through the experimental rats sports,we want to study the influence and the law of the supplement of Rhodiola sachalinensis to therelated indicatorsand of the rat brain tissue and serum in the process of the generation,accumulation and elimination of sports fatigue. We want to explore the alpine Rhodosin inelimination exercise fatigue and provide experimental evidence for the protective effect of therat brain.Method of the experiment: Healthy male SD rats for the study, in order to establishTreadmill training exercise fatigue model. after treadmill habilitation and Screening classifiedrandomly the rats into: quiet group, medication group, exercise group and exercise dosinggroup of sports fatigue.after the exercise-induced fatigue modeling success established, Inaccordance with the the dosage2.5mg/100g given gavage dosing group and medication groupin the morning, and in accordance with the Exercise to eliminate fatigue exercise program forexercise-induced fatigue rats in the afternoon. After four weeks, decapitate the rats in order toquickly remove the blood and brain tissue, then detected the rat brain tissue in SOD, MDA,GSH-PX of CAT and serum BUN, HB, CK.Experimental results:(1)Quiet group of brain tissue mitochondrial permeability transition pore opening than significantly greater than the normal group (P <0.01); Exercise group, medication group,sports medication group mitochondrial permeability transition pore opening than significantlyless than the normal group and quiet group (P <0.01);More significantly less than the degreeof opening of the mitochondrial permeability transition pore sports medication group exercisegroup, the treated group (P <0.01);The degree of openness of the mitochondrial permeabilitytransition pore in the exercise group and the medication group no significant difference; Thedegree of openness of the sport medication group and the normal group, the mitochondrialpermeability transition pore was no significant difference.(2) MDA content in brain tissue and serum CK activity, BUN concentrations for thegroup for quiet and execise are more significant than the normal group (P <0.01); the braintissue MDA for medication group was significantly higher than the normal group (P <0.05);serum CK activity, BUN content for the medication group are more significant than thenormal group (P <0.01); brain tissue SOD, GSH-PX, CAT activity and serum Hb content forquiet group are significantly lower than the normal group (P <0.01).(3) The brain tissue MDA content and serum CK activity, BUN levels for the exercisegroup, medication group and movement medication group were significantly lower than thequiet group (P <0.01); the brain tissue SOD, GSH-PX, CAT activity of Exercise group,medication group was significantly higher than the quiet group (P <0.05); the brain tissueSOD, GSH-PX, CAT activity for Sports medication group were the significantly higher thanthe quiet group (P <0.01); serum Hb content of Exercise group, medication group, sportsmedication group were significantly higher than the quiet group (P <0.01).(4) The brain tissue MDA content, SOD activity, GSH-PX activity, CAT activity andserum CK activity, BUN content, Hb content for the exercise group, the medication group arenot significant differences remained level.(5) The brain tissue MDA content and serum BUN concentrations for sports medicationgroup are significantly lower than the exercise group and the treated group (P <0.05);the braintissue CK activity for sports medication group was significantly lower than the exercise groupand the treated group (P <0.01);The brain tissue SOD, GSH-PX, CAT activity and serum Hbcontent for sports medication group were significantly higher than the exercise group and thetreated group (P <0.01).Conclusion: The experimental conclusion:(1) Exogenous complement of the mountain Rhodosin can reduce the content of MDAandiThe degree of openness of the mitochondrial permeability transition pore, Ncrease ofSOD, GSH-PX, CAT activity. This shows the mountain Rhodosin has a good anti-lipidperoxidation and reduce peroxidation of brain tissue damage and promote the recovery ofsports fatigue.(2) The mountain Rhodosin can reduce serum CK activity and BUN levels, increaseserum Hb content and alleviate the fatigue generated. It also can enhance athletic ability, andbeneficial the process of aerobic metabolism, promote recovery from fatigue.(3) Compared to quiet method, exercise and medication method for the ratexercise-induced fatigue recovery are significantly better. The effect of the movement and themedication for the recovery of rats with exercise-induced fatigue played has no significantdifferences. Sports and medicine method on the recovery of rats with exercise-induced fatiguesignificantly are better than the method of quiet, exercise and medication. |
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