Effects Of Solanesol On Myocardium Free Radical Metabolism And Crrelation Index Of Serum During The Recovery Period Of Exercise-induced Fatigue Rats

The process of high intensity exercise, the increase in free radicals in the body’sown antioxidant system difficult to get rid of excess free radicals, sports injuries andfatigue occurred. Exogenous antioxidant supplementation can delay or reverse theoxidative stress caused by a variety of chronic disease management process and theexercise-induced fatigue and development, increase exercise, especially aerobicexercise capacity. Solanesol an unsaturated polyisoprene alcohol, is four times thesesquiterpene alcohol. Solanesol with nine isoprene groups and a number ofnon-conjugated double bonds, it has a very strong absorption of the performance offree radicals. Solanesol can be used as for the synthesis of isoprene units, ubiquinonebiologically active substances, such as coenzyme Q₁₀and vitamin K₂. Coenzyme Q₁₀is a metabolic activator, can change the state of cells and tissue hypoxia, at the sametime, coenzyme Q₁₀or the cells natural antioxidant, inhibition of mitochondrialperoxidation, to protect the integrity of the biofilm structure.The purpose of the experiment: in the sports training, sports fatigue andaccumulation and elimination of a continuous process. Exercise test in rats, the studyof fatigue during exercise and recovery generation, accumulation and clear thegradual, continuous process to supplement the solanesol incremental exercise loadtraining to exhaustive exercise-induced fatigue in rat myocardium and serumindicators of the impact of laws, designed to explore the complement of solanesoldelay exercise-induced fatigue generated and accelerated the elimination of fatigue, aswell as protective effects on myocardial cells provide the experimental basis.Methods: Experimental healthy male SD rats for the study, Treadmill trainingexercise fatigue model. Treadmill to adapt to the training, screening, rats wererandomly divided into: a quiet group （UT）; movement instantly group （TC1）,recovery6h group （TC2） and restore the24h group （TC3）; sports small dose of theimmediate group （TST1） recovery6h group （TST2） and recovery24h （TST3）; sportsdose the instant group （TLT1）, restore6h group （TLT2to） and recovery at24h （TLT3）.Dose group, in accordance with the dosage3mg/100g （small doses）,6mg/100g （highdose） given orally every morning, afternoon, according to the sports fatigue programfor training, in addition to a quiet group, other groups Incremental Exercise weeks, in the middle does not rest, one day after two weeks of training, rats in addition to aquiet group, all other group the last time all the speed of30m/min Exhaustive. Ratsafter exhaustive, according to the different recovery time, the removal of the blood ofthe eye and then off marrow were sacrificed, and quickly removed the heart, weredetected in rat myocardial tissue SOD, GSH-Px and MDA, the CAT, SDH, and LDHand blood BUN and CK.Results:（1） Sports exhaustive instantly TST myocardial tissue activity of SOD, GSH-PX,CAT, and LDH, SDH, and SOD/MDA ratio was significantly （P <0.01） higher thanthe TC, the TLT has also been increased, and TC and TST no significant difference;the TST myocardial organization MDA activity significantly with sex （P <0.01） lowerthan the TC and the TLT, the TST serum CK activity minimum, with the TC and theTLT without significantly with the difference, the TST serum BUN significantly withsex （P <0.05） is lower than the TC, no significant difference with the TLT.（2） Sports exhaustive recovery6h, the TST myocardial tissue GSH-PX and LDH,SDH activity and the SOD/MDA ratio was significantly （P <0.01） higher than theTC, with sex （P <0.05） and significantly higher than the TLT; the TSTserum CK,BUN, activity was significantly （P <0.05） lower than the TC, and TST serum BUNwas significant （P <0.05） lower than the TLT.（3） Sports exhaustive recovery to24h, the TST myocardial GSH-PX and CATand LDH, SDH activity and SOD/MDA ratio was significantly （P <0.01） higher thanthe TC, which, TST myocardial tissue CAT and LDH, activity significantly （P <0.01）higher than the TLT and the SOD/MDA ratio; the TST serum CK, BUN and activitywas significantly （P <0.01） lower than the TC, TST serum BUN was significant （P<0.05） lower than the TLT.Experimental conclusions:（1） exogenous supplement of exogenous solanesol alcohol can be improved tovarying degrees movement in rats recovering from myocardial SOD/GSH-PX andCAT activity of MDA ratio. Description solanesol has good anti-lipid oxidation can bereduced by a large number of free radicals caused by myocardial ischemia andreperfusion damage and myocardial cell apoptosis rate, to protect the myocardial cell membrane structural and functional integrity, and promote exercise fatigue recovery.（2） Solanesol can improve movement in rats recovering from cardiac LDH, SDHactivity, lower serum CK activity and blood urea nitrogen content, and produce torelieve fatigue and enhance exercise capacity; the process of aerobic metabolism, andpromote sport when myocardial energy supply and fatigue recovery.（3） dose on the movement in rats recovering from fatigue better than large doses.