| As the high-speed development of economic today, human resources has gradually become the "first factor" of organization development. The essence of enterprise competition is transferred to the talent competition, but the high staff turnover has threaten the company’s normal operation, so how to keep employees’ loyalty is critical for the business, as well as reducing staff turnover. While for small and medium-sized enterprises, the brain drain problem research is particularly important, based on this, will put forward the corresponding counter-measures of human resource management practice.Firstly,this paper sorts and defines the meaning of brain drain, and classifies,through the analysis of a series of theoretical models and research results at home and abroad,. But after analysis, although theory research results are relatively mature abroad, but they are not suitable for the actual situation of our country enterprise staff turnover. Based on that management itself has the stronger dependence on the basis of the environment, what this paper analysis are combined with the actual situation of our country enterprise staffs loss. Secondly,based on sorting the talent flow’s impact on small and medium-sized enterprises and the influencing factors of talent flow, establish the thrust force model, and use the related theory influence mechanism and the way of analysis, and then put forward to prevent the brain drain of the dynamic management process. It can be said that the countermeasures based on mechanism analysis, dynamic management, the practice of the comprehensive analysis can be used as the main innovation of this study. Finally, combined with HZ pharmaceutical company, analyzes the present situation of brain drain, the main reason, and the influence of brain drain on the company, etc., put forward the corresponding countermeasures for practice. It is wished that related research conclusions can provide practical guidance and reference for small and medium-sized enterprises. |