| Objective:To observe the curative effect of points catgut embedding therapy for treatment of menopausal diabetic women; To explore the impact of reproductive endocrinology and glycometabolism with acupoint catgut embedding therapy on menopausal diabetic women.Method:Select menopausal women accorded with the diagnostic standard of diabetes, those menopausal women are between the ages of45-55years old. A total of64cases of menopausal women with diabetes were randomly divided into test group(n=32)and control group(n=32) according to the time sequence of seeing doctor. Patients in both groups on the basis of the diabetes education, diet therapy and exercise therapy, are gave regular hypoglycemic drugs or insulin subcutaneous injection according to the glucose concentration. In the test group, on the basis of drug treatment, every two weeks of Catgut Embedding was offered. Point selection:Shenshu(double), Sanyinjiao(double), Guan Yuan as the main points, Aid with secondary points based on syndromes.10weeks composed a treatment course; After a treatment course, the effect is evaluated. Following observation indexes will be detected in the beginning and end of the treatment:1. The elbow venous bloodserum estradiol(E2), luteinizing hormone(LH), follicle stimulating hormone(FSH), testosterone(T); fasting blood glucose (FPG),glycosylated hemoglobin (AbAlc), fasting insulin (FINS),and liver and kidney function indexes will be measured before and after treatment. 2.To Score symptoms and signs with symptom scale based on "Guiding principle of clinical research on new drugs of traditional Chinese medicine in the treatment of diabetes"3. Observe the quality of patients life before and after treatment by Type2diabetes quality of life scale(DMQLS).Result:1. There have no significant difference between two groups in age level, culture level and course of disease(P>0.05), two groups are comparable.2. Influence to curative effectThe experimental group was higher than the control group about overall effect of score, but there was no significant difference(P>0.05). The two groups may have similar short-term curative effection, the result is need some further study to be confirmed.3. Influence to life qualityThe score of life quality scale were not significantly different in two group before treatment; There were no obvious decline in Disease dimension, Psychological dimension, Satisfaction dimension in test group after treatment (P>0.05), the rest of the dimension decreased significantly (P<0.05), especially in the Physical dimension(P<0.01); There were no obvious decline in Disease dimensions, psychological dimension, satisfaction dimension in control group after treatment (P>0.05), while the score of physical dimension, social dimension, general appropriate dimension and total score were decreased significantly (P<0.05); Compare the difference between two groups before and after treatment, test group’s score decreased significantly in physical dimension, social dimension, general appropriate dimension and total score dimension than control group (P<0.05), the rest of the field has no significance (P>0.05).4. Influence to estradiol levelBefore this treatment, two groups has been compared about estradiol level by t test, there have no significant difference (P>0.05), two groups are comparable. Estradiol of two groups were compared in group by t test after treatment, there was a significant difference in test group (P<0.01); there was no significant difference in control group (P<0.05); The result show that acupoint catgut embedding therapy effectively regulate estradiol. Estradiol were compared between two groups by t test after treatment, it has a significant difference (P<0.05); The result show that acupoint catgut embedding has a positive effect on the regulation of estradiol level.5. Influence to FSH, LH, T levelBefore this treatment, two groups has been compared about FSH, LH, T level by t test, there have no significant difference (P>0.05), two groups are comparable. FSH、1H、T of two groups were compared in group by t test after treatment, there was a significant difference in test group(P<0.01), there was no significant difference in control group(P<0.05). Compare the difference between two groups by t test after treatment, LH、T have a significant difference (P<0.05), FSH have very significant (P<0.01)6. Influence to glycometabolismBefore treatment, the FPG, FINS, AbAlc level of two groups have been compared by t test, there have no significant difference(P>0.05), two groups are comparable. Compare the FPG, FINS, AbAlc level of two groups by t test after treatment, there was a significant difference in test group (P<0.01); there have very significant in control group(P<0.01). Compare the difference between two groups by t test after treatment, FPG、FINS have a significant difference (P<0.05), AbAlc has no significant difference (P<0.05).7. In the test group, compare E2with FPG before treatment, the correlation coefficient is-0.449(P<0.05), they have negative correlation; compare E2with FINS before treatment, the correlation coefficient is-0.069(P>0.05), it have been considered have no linear correlation between them; compare E2with AbAlc before treatment, the correlation coefficient is-0.159(P>0.05), it have been considered have no linear correlation between them.8. The change of E2before and after treatment in test group compared with the change of FPG before and after treatment in test group, correlation coefficient is-0.478(P<0.05), they have negative correlation; The change of E2before and after treatment in test group compared with the change of FINS before and after treatment in test group, correlation coefficient is-0.706(P<0.05), they have negative correlation; the change of E2before and after treatment in test group compared with the change of AbAlc before and after treatment in test group, correlation coefficient is-0.204(P>0.05), it is not considered a linear correlation between them.9. Safety comparison between the two groups of liver and kidney function before and after treatment, there were no significant differences (P<0.05), both the liver and kidney function level were in the normal range. Two methods of treatment had little effect on liver and kidney function in short term.Conclusion:1. Basic hypoglycemic combined with acupoint catgut embedding therapy have a positive effect on improving the life quality of patients with menopausal diabetic women. The recent therapeutic effect of acupoint catgut embedding for treatment of menopausal diabetic women is not clear, it is need some further study.2. There have a positive regulatory role in hypothalamic pituitary ovarian axis of menopausal diabetic women by using acupoint catgut embedding therapy, it can improve their low estrogen level, reduce FSH、LH level.3. Acupoint catgut embedding therapy can regulate glucose metabolism of menopausal diabetic women, reducing fasting blood glucose level, fasting insulin levels, effectively alleviate insulin resistance, however, the effect on glycated hemoglobin is uncertain.At the same time, the results show that estrogen plays an important role on glucose metabolism during the acupoint catgut embedding process. There is a correlation between the changes of estrogen levels and glucose metabolism. It provides a new approach for diabetes in climacteric in prevention and treatment.4. Prevention and control for adverse reaction in acupoint catgut embedding therapy have been made during the process of test, evaluation of liver and kidney function and other safety indicators were detected, it ensure the safety of acupoint catgut embedding therapy for menopausal diabetic. |
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