The Expression Of Survivin And Bcl-2 In Oral Verrucous Carcinoma And Their Correlation

Objective:To study the expression and the relationship of survivin and bcl-2 in oral verrucous carcinoma(OVC)and oral squamous cell carcinoma(OSCC)so as to investigate their role in the development and prognosis of OVC and OSCC.Methods:15 cases of oral normal mucosa(NM),15 cases of OVC(8 cases of exogenic type and 7case's of cystoid/infiltrative type)and 30 cases of OSCC(15cases wdSCC and 15 cases md/pdSCC)were used to detect the expression of survivin and bcl-2 by immunohistochemistry S-P method.Results:1.The protein expression of survivina.The expression of survivin in OVC and OSCC were higher than in NM(both P＜0.01).There was no difference of the expression of survivin between OVC and OSCC(P＞0.05).b.The expression of survivin in exogenic type OVC was significantly lower than cystoid/infiltrative type OVC,wd-OSCC and md/pd-OSCC(P＜0.05).There was no difference of the expression of survivin among cystoid/infiltrative type OVC,wd-SCC and md/pd-SCC(P＞0.05).c.Survivin expression of OSCC was associated with lymph node metastasis(p＜0.01),positive rates were higher in patients displaying lymph node metastasis than no metastasis.And there was no significant difference in age,sex of the patients,as well as the tumor sites,differentiated grades and clinical stages(p＞0.05)2.The protein expression of Bcl-2a.The expression of Bcl-2 in OVC and OSCC were higher than in NM(both P＜0.01).There was significant difference of the expression of Bcl-2 between OVC and OSCC(P＜0.05).b.The expression of Bcl-2 in exogenic type OVC was significantly lower than cystoid/infiltrative type OVC,wd-OSCC and md/pd-OSCC (P＞0.05).There was no difference of the prontein expression of Bcl-2 among cystoid/infiltrative type OVC,wd-OSCC and md/pd -OSCC (P＞0.05).c.Bcl-2 expression of OSCC was.associated with lymph node metastasis(p＜0.01),positive rate were higher in patients displaying lymph node metastasis than no metastasis.And there was no significant difference in age,sex of the patients,as well as the tumor sites, differentiated grades and clinical stages(p＞0.05).3.In OVC and OSCC the expression of survivin was correlated with the expression ofBcl-2(OVC:r=0.591,p＜0.05;OSCC:r=0.539,p＜0.05)Conclusion1.Survivin and Bcl-2 may play a key role in the carcinogenesis and development of OVC and OSCC.2.And it also showed part of cystoid/infiltratie type OVC can have a higher potential of invade and metastasis than exogenic type OVC.3.Apoptosis related gene Bcl-2 may have a synergistic role with survivin in pathogenesis and progression of OVC and OSCC.